Expression of intrarenal angiotensin Ⅱ is correlated with kidney fibrosis in primary IgA nephropathy patients
10.3760/cma.j.issn.1001-7097.2011.07.006
- VernacularTitle:原发性IgA肾病患者肾脏局部血管紧张素Ⅱ表达与肾脏纤维化相关
- Author:
Xiaoyan ZHANG
;
Wenlv LV
;
Jie TENG
;
Yihong ZHUNG
;
Xiaoqiang DING
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,IgA;
Renin-angiotensin system;
Fibrosis;
Estimated glomerular filtration rate;
Katafuchi score
- From:
Chinese Journal of Nephrology
2011;27(7):488-491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression and regulation of components of intrarenal renin-angiotensin system (RAS) and the correlation between intrarenal angiotensin Ⅱ (Ang Ⅱ) expression and clinicopathological injury index in primary IgA nephropathy patients. Methods Expressions of intrarenal RAS components were assessed by immunohistochemistry staining (IHCS). Correlation among intrarenal RAS components and of intrarenal Ang Ⅱ expression with blood pressure, estimated glomerular filtration rate (eGFR), 24-h urinary protein and Katafuchi score in 36 primary IgA nephropathy patients were examined. Results There were positive correlations between positive IHCS area of intrarenal renin and Ang Ⅱ (r=0.43, P＜0.01), angiotensiongen and Ang Ⅱ (r=0.34, P＜0.05). There was negative correlation between positive IHCS area of intrarenal Ang Ⅱ and eGFR (r=-0.61, P＜0.01). There was positive correlation between positive IHCS area of intrarenal Ang Ⅱ and pathological chronicity index (ρ=0.39, P＜0.05), index of interstitial cell infiltration (ρ =0.52, P ＜0.05). Conclusion Expression of intrarenal Ang Ⅱ is positively correlated with expression of intrarenal renin and angiotensinogen, and plays an important role in kidney fibrosis in primary IgA nephropathy.
