Effects of p90 ribosomal S6 kinase pathway in breast cancer and its mechanism

VernacularTitle:p90核糖体S6激酶通路在乳腺癌中的作用及其机制
Author: Xia BING ; Wang GANG
Publication Type:Journal Article
Keywords: Ribosomal protein S6 kinases,90-kDa; Breast neoplasms; Cell proliferation; Survival:Neovascularization,pathologic
From: Journal of International Oncology 2011;38(6):441-444
CountryChina
Language:Chinese
Abstract: p9O ribosomal S6 kinases(BSKs)are overexpressed in 50% human breast cancer. RSKs enhance the proliferation of breast cancer cells by regulating several key breast cancer-related proteins. They also improve survival of the breast cancer cells through regulating translocation and translation of mRNA. In addition. RSK promotes tumor angiogenesis by interaction with estrogen receptor. However, RSK4 may play an inhibitory role in breast cancer. In general, except RSK4,RSKs may become promising targets of breast cancer therapy.