Prognosis evaluation for gastrointestinal stromal tumor
10.3760/cma.j.issn.1673-422X.2011.05.019
- VernacularTitle:胃肠道间质瘤的预后评估
- Author:
Yian ZHANG
;
Chouwen ZHU
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Gene;
Mutation;
Immunohistochemistry;
Histology
- From:
Journal of International Oncology
2011;38(5):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal stromal tumor( CIST) is the most common form of mesenchymal tumor of the gastrointestinal tract. Most GISTs characteristically harbor activating mutations of c-kit or PDCFRA( platelet derived growth factor receptor alpha, PDGFRA). All CISTs should be regarded having malignant potential. Tumor size and mitotic count, as two basic progonstic factors for primary CISTs, are largely site dependent. Most c-kit mutations have been found in exon 11,9,13,17 while PDGFRA mutations re found in exon 18,12,14.The sites and types of mutions are associated with the prognosis of CIST. Histopathology and immunohistochem-istry are another two factors predicting tumor outcome.
