Aberrant L1 Cell Adhesion Molecule Expression in Cancer: In View of Proliferation, Migration and Invasion.
10.11106/jkta.2013.6.2.91
- Author:
Koon Soon KIM
1
Author Information
1. Research Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. kunsunkim@naver.com
- Publication Type:Review
- Keywords:
L1CAM;
Anaplastic thyroid carcinoma
- MeSH:
Cell Transformation, Neoplastic;
Endothelial Cells;
Epithelial Cells;
Membrane Glycoproteins;
Neural Cell Adhesion Molecule L1*;
Neurons;
Prognosis;
Thyroid Neoplasms
- From:Journal of Korean Thyroid Association
2013;6(2):91-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
L1 cell adhesion molecule (L1CAM) is a 220-kDa type I membrane glycoprotein and is normally expressed in neuronal cells, endothelial cells, and renal epithelial cells. Recent clinical studies demonstrated aberrant L1CAM expression in various cancers, especially at the invasive area of cancers. L1CAM has a key role in tumorigenesis, tumor invasion, and it is associated with a poor prognosis of cancer. Anaplastic thyroid carcinoma (ATC) has a highly poor outcome and it is resistant to conventional treatment. In this review, I discuss the biological role of L1CAM in proliferation, migration, and invasion in the ATC.
