Expression of tumor necrosis factor a and correlation with estrogen receptor in breast cancer
10.3760/cma.j.issn.1006-9801.2011.07.005
- VernacularTitle:肿瘤坏死因子α在乳腺癌中的表达及其与雌激素受体的相关性
- Author:
Di ZHANG
;
Jiancheng TU
;
Hanning HU
;
Gui YANG
;
Xiaogai LI
;
Mingxia YU
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-alpha;
Estrogen receptors;
Breast cancer
- From:
Cancer Research and Clinic
2011;23(7):450-452
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of tumor necrosis factor -α (TNF-a) and correlation with TNF-a in breast cancer. Methods We used SABC method to detect the expression of TNF-a in 112 cases of primary breast cancer, and analysis the relationship between TNF-α with histologic grades and ER. Results The positive expression rate of TNF-α in breast cancer was higher than those of normal tissues and lobular hyperplasia of the breast (X2 =8.573, P =0.014). There was no significant correlation between histologic grades and TNF-α (X2 =1.304, P =0.521). TNF-a had a positive correlation with ER in breast cancer (X2=11.949, P =0.001). Conclusion The positive expression rate of TNF-α in breast cancer was higher than those of normal tissues and lobular hyperplasia of the breast.TNF-α had a positive correlation with ER in breast cancer, but the exact mechanism is unclear.
