Research development of APC gene promoter methylation in gynecological cancer
10.3760/cma.j.issn.1006-9801.2011.06.025
- VernacularTitle:妇科肿瘤与APC基因启动子甲基化研究进展
- Author:
Yan YAN
;
Chen YONG
- Publication Type:Journal Article
- Keywords:
Adenomatous polyposis coli gene;
Methylation;
Gynecological cancer
- From:
Cancer Research and Clinic
2011;23(6):428-430
- CountryChina
- Language:Chinese
-
Abstract:
Adenomatous polyposis coli gene is an important anti-oncogene of the Wnt signaling pathway. The promoter hypermethylation of APC gene can effect the expression of APC mRNA and APC proteinum, which can make Wnt signaling pathway anomalous. Recently. the promoter hypermethylation of APC Gene in gynecological tumors is found in many studies, and it is related to the aggravation level of tumor.This paper reviews the influencing factors and progress of promoter methylation of APC gene in Gynecological cancer.
