Research progress of selective mGluR1 antagonists.
- Author:
Yilei YANG
;
Wei SUN
;
Cheng PENG
;
Xiaoye ZHANG
;
Xiaohong YANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(10):1167-72
- CountryChina
- Language:Chinese
-
Abstract:
As an important member of metabotropic glutamate receptors (mGluR), metabotropic glutamate receptor 1 (mGluR1) plays an important role in the signal transduction of central nervous system. Selective mGluR1 antagonists can block the signaling pathway activated by mGluR1 and exert a series of physiological actions including analgesia, antianxiety, antidepression, etc. Currently, the discovery and modification of selective mGluR1 antagonists have become a hot research focus. This paper reviews the structural catalogs of selective mGluR1 antagonists and their structure-activity relationships in the last decade.
