Progress in the study of allergic disease drugs targeting on IgE/FcepsilonRI signaling pathway.
- Author:
Zhongcheng LIU
;
Hailang SHI
;
Yanfen ZHANG
;
Lijun ZHAO
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(10):1161-6
- CountryChina
- Language:Chinese
-
Abstract:
Allergic diseases have become global social health problems. The binding of IgE with its high affinity receptor FcepsilonRI plays a key step in I-type allergy. Recently, more and more key molecules on the IgE/FcepsilonRI signaling transduction pathway were to be the drug candidates against allergic diseases, with in-depth study of FcepsilonRI signal pathway gradually. The main drugs include molecule antibodies, peptides, vaccines, fusion proteins, small molecules, and other drugs related to IgE/FcepsilonRI. The recent progress in the study of mechanisms of representative drugs targeting on IgE/FcepsilonRI signaling pathway was reviewed in this article.
