A Case of Cytomegalovirus Colitis which Occurred During Treatment of Hemophagocytic Syndrome.
- Author:
Sang Nam BAE
1
;
Sung Ryon AHN
;
Yun Jin LEE
;
Young Tak LIM
;
Jae Hong PARK
;
Kyung Un CHOI
;
Chang Hun LEE
Author Information
1. Department of Pediatrics, College of Medicine, Busan National University, Busan, Korea.
- Publication Type:Case Report
- Keywords:
Cytomegalovirus;
Colitis
- MeSH:
Abdominal Pain;
Bile Ducts;
Biopsy;
Child;
Colitis*;
Colon;
Cytomegalovirus*;
Dexamethasone;
Diarrhea;
Drug Therapy;
Etoposide;
Female;
Hemorrhage;
Histiocytosis;
Humans;
Immunohistochemistry;
Lymphohistiocytosis, Hemophagocytic*;
Opportunistic Infections;
Stevens-Johnson Syndrome;
Ulcer
- From:Journal of the Korean Pediatric Society
2001;44(9):1075-1080
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cytomegalovirus(CMV) colitis is an important opportunistic infection in immunocompromised individuals. The clinical symptoms are abdominal pain, diarrhea, colonic hemorrhage and perforation. The endoscopic appearance shows three characteristic features with focal or diffuse inflammatory changes, submucosal hemorrhagic spots, and well demarcated ulcers. We experienced a case of CMV colitis in an 8-year-old girl presented with Stevens-Johnson syndrome, vanishing bile duct syndrome and infection-associated hemophagocytic histiocytosis, which developed during chemotherapy with etoposide and dexamethasone for hemophagocytic syndrome. The impaired immunity caused by chemotherapy is the most likely possible cause of CMV colitis in this case. We confirmed this case by endoscopic findings, the presence of cytomegalic cells on mucosal biopsy specimens, immunohistochemistry with monoclonal antibody to CMV antigen, and serologic study, and report with a brief review of the literature.
