Diterpene constituents of Tripterygium willfordii (II).
- Author:
Sui LIN
;
Huiqing QUE
;
Huayi PENG
;
Liping QIAN
;
Shunmin GUO
;
Yuanchao LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(8):942-5
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).
