A novel hemiacetal from the marine-derived fungus Penicillium citrinum.
- Author:
Mini NI
;
Xiaoyan ZHOU
;
Xuan HE
;
Qianqun GU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(9):1098-100
- CountryChina
- Language:English
-
Abstract:
A novel hemiacetal, citrinacetal (1) was isolated from a marine-derived fungus Penicillium citrinum by column chromatography on silica gel, Sephadex LH-20 and semi-preparative HPLC. Its structure and stereochemistry was established on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic methods. The NMR spectrum showed this compound exists in solution as a mixture of two stereoisomers. The cytotoxic effect of compound 1 was evaluated in A-549, HL-60, HeLa, and K562 cancer cell lines. However, compound 1 only displayed weak cytotoxic activity on HL-60 cell, with IC50 value 77.4 micromol x L(-1).
