Research progress of zebrafish used in drug metabolism.
- Author:
Qiuxia CHEN
;
Su ZENG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(9):1026-31
- CountryChina
- Language:Chinese
-
Abstract:
Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.
