Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as anti-cancer agents.
- Author:
Yanxiang WANG
;
Wuli ZHAO
;
Chongwen BI
;
Yangbiao LI
;
Rongguang SHAO
;
Danqing SONG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2012;47(2):200-5
- CountryChina
- Language:Chinese
-
Abstract:
A series of novel N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and evaluated for their anti-cancer activities. Among these analogs, compound 9a exhibited the potential anti-cancer activities on HepG2 and HCT116 cells with IC50 values of 2.52 and 1.99 microg x mL(-1), respectively. Cell cycle was blocked at S phase of HepG2 cells treated with 9a by flow cytometry detection. Our results provided a basis for the development of a new series of anti-cancer candidates.
