Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives.
- Author:
Wenhu LIU
;
Shibao WANG
;
Xian YU
;
Xinqiang YIN
;
Yi LIU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2012;47(2):194-9
- CountryChina
- Language:Chinese
-
Abstract:
To explore new agents of gamma-aminobutyric acid (GABA) derivatives with more potent antiepileptic activity, a series of 4-(2-acetoxybenzoylamino) butyramide derivatives were designed and synthesized. All of the novel compounds (5a-51) were synthesized from GABA as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that all target compounds displayed strong antiepileptic activities and were worth for further study. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyramide derivatives was also discussed preliminarily.
