Regulatory mechanism underlying pathogen biofilm formation and potential drug targets.
- Author:
Tingyu SHI
;
Wanyan DENG
;
Jianping XIE
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2012;47(2):135-43
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial communities usually develop biofilms abound in nature niche. The development of biofilm is a highly dynamic and complex process coordinated by multiple mechanisms, of which two-component system and quorum sensing are two well-defined systems. Biofilm is involved in the virulence of many pathogens. Therefore, targeting the key factors involved in the biofilm formation represents a novel and promising avenue for developing better antibiotics.
