Study on semi-synthetic transforming technology for the natural product of isocorydione.
- Author:
Tiancai ZHANG
;
Helin YE
;
Junxi LIU
;
Duolong DI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(12):1471-5
- CountryChina
- Language:Chinese
-
Abstract:
Transforming technology for semi-synthesized isocorydione from the natural product ofisocorydine was studied. The factors affecting on the reaction yield were investigated. UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione. The optimum reaction conditions were determined as following: reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 degrees C and the ratio of isocorydine to Fremy's radical was 1 : 2. Under the optimum conditions, the yield could reach up to 50.0%. The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.
