Effects of Tea Polyphenols on Cerebral Lipid Peroxidation,Liver and Renal Functions in Rats after Repeated +Gz Stress
- VernacularTitle:茶多酚对重复+Gz暴露大鼠脑脂质过氧化反应和肝肾功能的影响
- Author:
Hao ZHAN
;
Yimei XIN
;
Guixiang TANG
;
Liming CHEN
;
Jing WEN
- Publication Type:Journal Article
- Keywords:
acceleration stress;
lipid peroxidation;
liver function;
renal function;
antioxidant;
tea polyphenols;
rat
- From:Space Medicine & Medical Engineering
1999;12(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of repeated +10 Gz stress on cerebral lipid peroxidation,liver and renal function in rats and the prophylactic effects of antioxidant tea polyphenols(TP).Method Twenty-four male Wistar rats were randomly divided into three groups(n=8 each):group A(control),group B(+10 Gz),and group C(TP).Group B and C were exposed to repeated +10 Gz stress(each for 30s,onset rate about 0.5 G/s,3 times/d with +1 Gz 1 min intervals,3 d/wk,4 weeks in total),but group A was only submitted to +1 Gz.TP(200 mg/kg) was given orally in group C about 1 h prior to the +Gz experiment,while distilled water was given in group A and B.Lipid peroxidation in the brain,liver and renal functions and serum lipids were determined.Results As compared with the control,lipid peroxidation in rat cerebral homogenate,mitochondria and cytoplasm was significantly increased( P<0.05),and serum creatinine concentration was markedly elevated after repeated +10 Gz stress(P<0.01).But,TP had significant inhibitory effect on +10 Gz stress induced peroxidative injury in rat brain and reduced the serum creatinine level.There were no differences of serum triglyceride and total cholesterol concentrations and glutamic-pyruvic transaminase activity among the three groups.Conclusion These results indicated that repeated high +Gz stress could bring about peroxidative injury in brain and harmful effect on renal function,and natural antioxidant TP had signficant protective effects.
