DNA methylation and atherosclerosis
10.3760/cma.j.issn.1673-4165.2011.02.015
- VernacularTitle:DNA甲基化与动脉粥样硬化
- Author:
Xiaohui LIN
;
Qinghua LI
- Publication Type:Journal Article
- Keywords:
DNA methylation;
Arteriosclerosis;
Epigenetics
- From:
International Journal of Cerebrovascular Diseases
2011;19(2):151-156
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is the outcome of polygenic inheritance and interaction of environmental factors.It is one of the important the diseases controlled by the epigenetic laws.DNA methylation is the first discovered and well-studied epigenetic molecular mechanism.There are a variety of ways for the detection of DNA methylation,each has its advantages and disadvantages.The abnormal methylation modification of genomic DNA comprehensive hypomethylation and related candidate genes is closely associated with the occurrence and development of atherosclerosis.This article reviews the related research progress.
