Association between apolipoprotein E gene polymorphism and the dose for warfarin maintenance

VernacularTitle:载脂蛋白E基因多态性与华法林维持剂量的相关性
Author: Shengwen HUANG ; Baolin CHEN ; Daokang XIANG ; Ling HUANG ; Bangquan AN ; Guifang LI
Publication Type:Journal Article
Keywords: apolipoprotein E gene; genotyping; warfarin; personalized medicine
From: Journal of Central South University(Medical Sciences) 2011;36(3):212-216
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between the apolipoprotein E (apoE) gene polymorphism and the dose for warfarin individual maintenance. Methods The genotypes of 249 patients with warfarin treatment in maintenance doses were determined by PCR/DHPLC assay. The doses for warfarin maintenance were compared among patients with different genotypes. Results In the total of 249 patients, the frequencies of 2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, ε4/ε4 genotype were 1.20%, 15.66%, 1.80%, 72.29%, 9.24%, 0.80%, respectively; the allele frequencies of ε2, ε3, ε4 were 9.44%, 84.74%, 5.82%, respectively. The warfarin dose of group ε2 (ε2/ε2, ε2/ε3) was (3.24±1.36) mg/d, slightly higher than that of group ε3 (ε3/ε3, 2.91±1.14 mg/d) or group ε4 [ε4/ε4, ε3/ε4, (2.98±1.05) mg/d], but the difference of the warfarin doses among the 3 groups did not reach statistical significance (F=1.848,P＞0.05). Conclusion ApoE polymorphism may be not a major genetic factor that influences the individual dose for warfarin maintenance.