NELL2 and its role in the secreation of gonadotropin releasing hormone
10.3760/cma.j.issn.1673-4408.2011.02.021
- VernacularTitle:NELL2及其在促性腺激素释放激素分泌中的作用
- Author:
Shasha ZHOU
- Publication Type:Journal Article
- Keywords:
NELL2;
Glutamate;
Gonadotropin releasing hormone
- From:
International Journal of Pediatrics
2011;38(2):162-166
- CountryChina
- Language:Chinese
-
Abstract:
The puberty and reproduction are regulated by the hypothalamic-pituitary-gonadal axis. The activation of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and an increase in GnRH is critical for the initiation of puberty. The mechanism of GnRH regulation for neurons activity is complicated, because many different factors can affect the secretion of GnRH. Glutamate is the main excitatory neurotransmitter, which can promote the secretion of GnRH through a variety of pathways. In recent years, relevant studies showed that NELL2 may influence the secretion of GnRH by regulating the secretion of glutamate or through other pathways,thereby affecting the onset of puberty. So NELL2 plays an important role in promoting neuronal growth,differentiation, neuronal plasticity maintenance and synapse transportation etc.
