Expression of intercellular adhesion molecule-1and HLA-DR antigens in uveitis
- Author:
Xu LI
;
Guiyun WANG
;
Xiaoguang ZHANG
;
Guiqin SUI
- Publication Type:Journal Article
- Keywords:
intercellular adhesion molecule-1;
immunohistochemistry;
human leuko-cyte antigen
- From:
Journal of Jilin University(Medicine Edition)
1999;25(4):393-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study the effects of intercellular adhesion molecule-1 (ICAM-1) and human leukocyte antigen (HAL-DR) on the immunopathologic process of uveitis. Methods:Imn- munohistochemical techniques were applied to detect their expression in eyes of both the health (20 cases from eye bank) and patients with uveitis (54 cases with 54 eyes which included 33 ex- ogenous uveitis and 21 endogenous one). Results:Both the two ant igens were detectable in the choroidal and retinal tissues in eyes of uveitis while all the normal eyes showed negative expres- sion of ICAM-1 and negative or little expression of HLA-DR (P＜0. 01). However,there was no statistically significant difference between exogenous and endogenous types (P＞0. 05). Conclu- sion: Both ICAM-1 and HLA-DR may be responsible for cell recognition and binding in the in- flarnmatory tissues. The co-expression of ICAM-1 and HAL-DR showed that these two factors might play an important role in the immunologic damage of the choroid and retina in uveitis.
