Prevention of experimental autoimmune anterior uveitis by anterior chamber-associated immune deviation
- VernacularTitle:通过前房相关免疫偏离阻止实验性自身免疫前葡萄膜炎
- Author:
Zhijie LI
;
Guanghua PENG
;
Zheng FENG
;
Chen LI
- Publication Type:Journal Article
- Keywords:
immune privilege;
immune deviation;
uveitis;
autoimmune;
bovine melanin protein
- From:
Recent Advances in Ophthalmology
1999;19(4):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective Experimental autoimmune anterior uveitis (EAAU) is a useful model for human anterior uveitis. The purpose of this study was to observe whether EAAU development could be prevented by anterior chamber-associated immune deviation (ACAID). Methods Bovine melanin protein (BMP) in phosphate-buffered saline (PBS) was injected into the anterior chamber of the right eye of rats; control animals were injected with PBS alone. Seven days later, all animals were immunized with BMP in complete Freund's adjuvant (CFA) and pertussis toxin. The severity and incidence of uveitis was monitored by clinical examination and histopathology. The delayed-type hypersensitivity (DTH) responses were evaluated by footpad swelling elicited by injection of BMP.Results Rats intraocularly injected with BMP showed a reduced severity and incidence of EAAU, and significantly suppressed DTH response compared to control rats.Conclusion These data suggest that the ACAID procedure can be utilized to prevent the development of EAAU.
