Advances in study of miR-106b-25 cluster in cancer
10.3760/cma.j.issn.1673-422X.2011.03.001
- VernacularTitle:微RNA-106b～25基因簇在肿瘤中的研究进展
- Author:
Anling ZHANG
;
Peiyu PU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Transforming growth factor beta;
Signal transduction;
miR-106b-25 cluster
- From:
Journal of International Oncology
2011;38(3):163-166
- CountryChina
- Language:Chinese
-
Abstract:
miR-106b-25 cluster is composed of miR-106b,miR-93 and miR-25,and is a paralogue of miR-17-92 cluster.Some studies have shown that the members in miR-106b-25 cluster abundantly expressed in many cancers.Over-expressions of these miRNAs promote the growth of tumor cells by negatively regulating p21 and p57,and suppress the apoptosis of tumor cells through inhibition of Bim.Moreover,high expression of miR-106b-25 cluster might endue tumor cells with resistance to inhibitory effect of cell growth induced by TGF-β signaling.
