Advances in the antitumor research of PARP inhibitor
10.3760/cma.j.issn.1673-422X.2011.03.008
- VernacularTitle:多聚二磷酸腺苷酸核糖聚合酶抑制剂抗肿瘤研究进展
- Author:
Xuyuan LI
;
Weibing LI
;
Yingcheng LIN
- Publication Type:Journal Article
- Keywords:
Poly(ADP-Ribose)Polymerase;
Neoplasms;
Enzyme inhibitors;
Synthetic lethality
- From:
Journal of International Oncology
2011;38(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
Poly ADP-Ribose Polymerase(PARP)plays an important role in the detection and repair of DNA damage.Inhibition of the PARP activity in the homologous-recombination defective cancer cell could lead to genomic instability and ultimately cause cell death.In preclinical study PARP inhibitors have demonstrated the capacity of enhancing sensitivity of cancel cells to chemotherapy agents and radiation.PARP inhibitors also showed antitumour potential in early clinical trials as monotherapy or combined with chemotherapy.
