Chemoprevention of colorectal cancer
10.3760/cma.j.issn.1673-422X.2011.03.020
- VernacularTitle:大肠癌的化学预防
- Author:
Ping ZHOU
;
Xinxing DUAN
;
Jian LIU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Chemoprevention
- From:
Journal of International Oncology
2011;38(3):224-227
- CountryChina
- Language:Chinese
-
Abstract:
Chemoprevention is the use of natural or synthetic substances to prevent、suppress or to reverse the development of colorectal cancer.Aspirin and cox-2 inhibitor are the most effective preventive agents.However,the gastrointestinal and cardiovascular adverse effects limit the application.Recurrent adenomas can be markedly reduced by a combination of difluoromethylornithine and sulinclac and with few side effects.5-aminosalicylate and ursodeoxycholic acid have become the focus of inflammatory bowel disease.The double roles of folate need further study.Statins and EGFR inhibitors have some effects,which are in early clinical studies.The article reviews the new progress of chemoprevention of colorectal cancer.
