Regulation of telomerase activity and gene therapy for cancer
10.3760/cma.j.issn.1673-422X.2011.01.006
- VernacularTitle:端粒酶活性的调节及其在肿瘤基因治疗中的研究进展
- Author:
Qianqian LI
;
Zhihua DENG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Telomerase;
Target therapy
- From:
Journal of International Oncology
2011;38(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
The hTERT gene promoter is a tumor-specific promoter, regulated by a number of factors.Modulation of the chromatin structure via DNA methylation or histone acetylation plays an important role in regulating the hTERT promoter. Recent study also found that glycogen synthase kinase -3 cytokines, macrophage colony-stimulating factor receptor 1, bone inducing factor -7, transcription factors c-myc inhibitor, transforming growth factor β, cyclopentenone prostaglandin regulate the activity of hTERT through various pathways. Telomelysin, the telomerase-specific replication competent oncolytic adenovirus, has been used in clinical settings.Various gene therapies based on hTERT are current under-way.
