Role of CXCR4 expression in progress and prognosis of breast cancer
10.3760/cma.j.issn.1673-422X.2011.01.012
- VernacularTitle:CXCR4表达对乳腺癌进展及预后的意义
- Author:
Hongwu CHEN
;
Guoying WU
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Receptors,CXCR4;
Neoplasm metastasis;
Prognosis
- From:
Journal of International Oncology
2011;38(1):36-38
- CountryChina
- Language:Chinese
-
Abstract:
CXCR4, a receptor for stromal cell-derived factor-1 (SDF-1, also know as CXCL12) and a member of the chemokine receptor family, has been shown to play an important role in the proliferation, migration, invasion and metastasis of breast cancer cells. CXCR4 expression is an early event in breast cancer development and may serve as a biomarker for early detection and diagnosis of breast cancer. Expression of CXCR4 has been demonstrated to correlate with metastasis and poor prognosis in breast cancer. Inhibition of CXCR4 expression may be a potential target of breast cancer treatment.
