Expression and clinical significance of EML4-ALK in non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2011.01.014
- VernacularTitle:EML4-ALK在非小细胞肺癌中的检测及其临床意义
- Author:
Li MA
;
Xiaohong HAN
;
Yuankai SHI
- Publication Type:Journal Article
- Keywords:
Carcinoma,Non-small-cell lung;
Echinoderm microtubule-associated protein-like 4
- From:
Journal of International Oncology
2011;38(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
The fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified as a new molecular target of non-small cell lung cancers (NSCLC). Stage Ⅰ and stage Ⅱ clinical trials have observed remarkably clinical efficacy of ALK inhibitors in NSCLC patients harboring EML4-ALK translocations, with response rates exceeding ＞ 80%. Investigation of EML4-ALK's biological functions and its correlation with clinical characteristics may shed some light on a new treatment strategy for NSCLC.
