Progress in models of pancreatic cancer
10.3760/cma.j.issn.1673-4203.2011.03.010
- VernacularTitle:胰腺癌动物模型的研究进展
- Author:
Dongfeng CHENG
;
Jinhua YE
;
Baosan HAN
;
Chenghong PENG
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Animal models;
Xenograft;
Carcinogen induced;
Genetically engineered
- From:
International Journal of Surgery
2011;38(3):173-176
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a highly malignant tumor. Animal models of pancreatic cancer included xenograft models, carcinogen induced models, genetically engineered models. Xenograft models are relatively reliable and feasible, but the growth pattern is different between serve immunodeficienct animals and human beings. Carcinogens induced models simulated the environmental factors to reconstruct the development of pancreatic cancer. But carcinogens could have other biological effects. Genetically engineered models could make the occurrence of pancreatic cancer at the molecular level. But it is difficult to control the transgenic product accurately. No model could meet all the needs of different experiments. It is important to choose a suitable animal model in different experiments.
