Feasibility of heme oxygenase- 1 ( HO- 1 ) gene transfer therapy in acute pancreatitis
10.3760/cma.j.issn.1673-4203.2011.03.011
- VernacularTitle:血红素加氧酶-1(HO-1)基因转染治疗急性胰腺炎的研究展望
- Author:
Feihu ZHANG
;
Jian FEI
;
Enqiang MAO
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Heme oxygenase-1;
Gene transfer
- From:
International Journal of Surgery
2011;38(3):177-179
- CountryChina
- Language:Chinese
-
Abstract:
Heme oxygenase- 1 ( HO- 1 ) can catalyze the decomposition of heme and the products of its enzymatic activity,including carbon monoxide, biliverdin, bilintbin and ferritin, can play a significant cytoprotective role in antagonizing inflammation, protecting cells from oxidative injury and cellular stresses. The method of gene transfer can maintain target gene expression for a long time,can regulate the inflammatory immune response. HO- 1 gene transfer has made marked results in research of numerous diseases. In this article,we give a review of feasibility of HO-1 gene transfer therapy in acute pancreatitis.
