MicroRNAs and solid tumors drug resistance
10.3760/cma.j.issn.1673-4203.2011.03.013
- VernacularTitle:Micr0RNAs与实体肿瘤化疗耐药
- Author:
Jianwei XU
;
Taiping ZHANG
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
Solid tumors;
microRNAs;
Chemotherapeutic agent;
Drug resistance
- From:
International Journal of Surgery
2011;38(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
Drug resistance is major obstacles in the successful treatment of malignant solid tumors. Multiple mechanisms involeve in development of cancer drug resistance. Recent research suggests dysregulation of microRNAs is associated with cancer drug resistance. The profiles of microRNAs in drug resistance cancer cells or tissues are different with sensitivity cells or tissues in various solid tumors. Restoring microRNAs could improve chemosensitivity of cancer cells. MicroRNAs expression profiles may provide a critical link for understanding mechanisms involved in chemoresistance. We can also find a specific marker for screening chemosensitivity patients through identification of the microRNAs patterns of drug resistance cells or tissues.
