Research progress of heparanase in malignant tumor
10.3760/cma.j.issn.1673-4203.2011.03.009
- VernacularTitle:乙酰肝素酶在恶性肿瘤中的研究进展
- Author:
Guoli CHEN
;
Lie WANG
- Publication Type:Journal Article
- Keywords:
Heparanase;
Tumor metastasis;
Heparanase inhibitor
- From:
International Journal of Surgery
2011;38(3):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Heparanase, an endo- β- D- glucuronidase, that cleaves heparan sulfate chains in heparan sulfate proteoglycans, has recently been found in mammalian. It may play a key role in tumor progression and metastasis. Here we disscuss its molecular structure, biochemical properties, expression in malignant tumor,mechanism in accelerating tumor metastasis and application in heparanase inhibitor.
