Mechanisms of CD4+ CD25 + regulatory T-cell suppression in tumor immunity
10.3760/cma.j.issn.1673-4203.2011.04.015
- VernacularTitle:CD4+CD25+调节性T细胞在肿瘤免疫中的作用研究
- Author:
Li LIU
;
Wenchuan WU
;
Baochi LIU
- Publication Type:Journal Article
- Keywords:
CD4 + CD25 + Treg;
Tumor immunity;
Immune response
- From:
International Journal of Surgery
2011;38(4):259-262
- CountryChina
- Language:Chinese
-
Abstract:
CD4 + CD25 + regulatory T- cell (Treg) play essential roles in maintaining self- tolerance, immune homeostasis and cancer immune system. Treg can suppress immune responses against self antigens or non-selfantigens such as tumor antigens. The immunosuppressive functions of Treg are widely acknowledged and have been extensively studied. Recent studies demonstrate the existence of Treg at tumor sites, implying that these Treg may induce antigen-specific and local immune tolerance. This review will discuss the ligands, mechanisms of immune suppression of Treg and its potential roles in cancer therapy.
