The role of cyclophilin A in the development of abdominal aortic aneurysm
10.3760/cma.j.issn.1673-4203.2011.04.018
- VernacularTitle:Cyclophilin A在腹主动脉瘤形成中的作用
- Author:
Kan HUANG
;
Shixiong HU
;
Sanming WANG
;
Lin PENG
- Publication Type:Journal Article
- Keywords:
Abdominal aortic aneurysm;
Cyclophilin A;
Pathogenesis
- From:
International Journal of Surgery
2011;38(4):270-274
- CountryChina
- Language:Chinese
-
Abstract:
Abdominal aortic aneurysms (AAA) is one kind of common vascular disease. Inflammation and matrix degradation in the vasculature are crucial for AAA formation, key mechanism of which include vascular smooth muscle cell(VSMC) senescence, oxidative stress, increased local production of proinflammatory cytokines, and increased activities of matrix metalloproteinase (MMPs). Cyp A, the member of cyclophilins,has a variety of physiological functions. It is highly expressed in VSMC, and plays an important role in the development of AAA, making it a new therapeutic target for such disease.
