Progress in the BRAFV600E mutation and papillary thyroid carcinoma
10.3760/cma.j.issn.1673-4203.2011.02.011
- VernacularTitle:BRAFV600E突变与甲状腺乳头状癌诊治研究进展
- Author:
Yanjun SU
;
Chang DIAO
;
Jianming ZHANG
;
Ruochuan CHENG
- Publication Type:Journal Article
- Keywords:
BRAF mutation;
Papillary thyroid carcinoma;
Diagnosis;
Therapeutics
- From:
International Journal of Surgery
2011;38(2):104-109
- CountryChina
- Language:Chinese
-
Abstract:
BRAFV600E mutation is the most common genetic alteration in the papillary thyroid carcinoma.It plays an important role in the tumorigenesis,invasiveness and metastasis of the papillary thyroid carcinoma.Testing of BRAFV600E mutation is of great value in diagnosis,which also can be used as a prognostic maker of papillary thyroid cancer.Inhibitors treatment targeted to BRAF kinase and its downstream effectors is a new area in the treatment of BRAFV600E mutated thyroid cancer.
