Function and interaction of dendritic cells and CD4+CD25+regulatory T cells in immune tolerance
10.3760/cma.j.issn.1673-4203.2011.02.016
- VernacularTitle:树突状细胞和CD4+CD25+调节性T细胞在免疫耐受中的作用及关系
- Author:
Ben MA
;
Xiao LI
;
Dajun ZHAO
;
Kefeng DOU
- Publication Type:Journal Article
- Keywords:
Dendirtic cell;
CD4+ CD25+ regulatory T cell;
Organ transplantation;
Immune tolerance
- From:
International Journal of Surgery
2011;38(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Induction of immune tolerance is characterized by high efficiency,low toxicity and economic advantages,and immune tolerance has very important significance in organ transplantation.In the establishment of immune tolerance,dendritic cells (DCs) play the key roles such as clonal deletion or clonal anerge,expressing t-cell inhibiting factors,activating helper T cells electively and inducing regulatory T cells,especially CD4 + CD25 + regulatory T cells,etc.Similarly,CD4 + CD25 + regulatory T cells whose primary target point is dendritic cell also have various functions such as affecting dendritic cells'maturing,restraining dendritic cells'antigen presentation to T cells,inhibiting the activation of T cells in non-specific ways and inducing immune tolerance.Current research shows,dendritic cells and CD4 + CD25 + regulatory T cells regard each other as target point and work synergetically.Here we mainly discuss the function and interaction of dendritic cells and CD4 + CD25 + regulatory T cells in the immune tolerance.
