Synthesis of three nitrogen derivatives and cytotoxicity of some derivatives of 4',5,6-trihydroxy-3,3',7-trimethoxyflavone isolated from Miliusa balansae
- Author:
Do Thi Thu Huong
- Publication Type:Journal Article
- Keywords:
Miliusa balansae, cytotoxicity
- MeSH:
Nitrogen;
chemical synthesis;
analogs & derivatives;
- From:Journal of Medicinal Materials - Hanoi
2004;9(3):69-72
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
3 nitrogene derivatives had been synthetized successfully from 4’,5,6-trihydroxy 3,3’,7-methoxyflavone (chrysosplenol C) isolated from Miliusa balansae Fin.& Gagnep. 10 derivatives of chrysosplenol C were prepared. These 13 compounds were tested for cytotoxicity against Hepatoma-G2. Among them, 4 showed moderate activity (IC50<5microgram/ml )
