Correlative study between the angiotensin converting enzyme gene polymorphism and cerebrovascular diseases in Naxi population in Yunnan province
10.3760/cma.j.issn.1673-4165.2011.02.005
- VernacularTitle:云南纳西族人群血管紧张素转换酶基因多态性与脑血管病的相关性研究
- Author:
Hong XU
;
Xijun FAN
;
Qihong YUAN
;
Lühua CHANG
;
Zhi NIE
;
Guoqiang HE
- Publication Type:Journal Article
- Keywords:
Peptidyl-dipeptidase A;
Polymorphism,genetic;
Stroke
- From:
International Journal of Cerebrovascular Diseases
2011;19(2):101-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the angiotensin-converting enzyme(ACE)gene insertion/deletion(I/D)polymorphism and cerebrovascular diseases in Naxi population in Lijiang,Yunnan province.Methods Fifty-eight Naxi patients with cerebral infarction,32 Naxi patients with intracerebral hemorrhage,and 50 sex- and age-matched Naxi healthy controls were recruited.Polymerase chain reaction-restricted fragments length polymorphism was used to detect the ACE gene polymorphism and perform bidirectional sequencing Results The DD genotype and the D allele frequency in the cerebral infarction group were significantly higher than those in the healthy control group(32.8% vs.16.0%,P = 0.045 and 54.3% vs.39.0%,P =0.025);while there were no significant differences in the DD genotype and the D allele frequency between the intracerebral hemorrhage group and the control group.The different types of cerebral infarction carried different allele frequencies,they were in order of cerebral embolism ＜ cerebral thrombosis ＜ lacunar infarction.The DD genotype in patients with lacunar infarction(40.0% vs.30.0%,P = 0.481 )and the D allele frequencies(63.3% vs.51.2%,P =0.257)were all higher than those in patients with cerebral thrombosis,but there were no significant differences.Conclusions The ACE DD genotype carriers were susceptible to cerebral infarction in Naxi poulation in Yunan province.
