Relationship between polymorphisms of lecithin cholesterol acyltransferase gene 608C/T or 511C/T and stroke in Chinese Han population in Hunan province
10.3760/cma.j.issn.1673-4165.2011.01.004
- VernacularTitle:卵磷脂胆固醇酰基转移酶基因608C/T和511C/T多态性与湖南地区汉族人卒中的关系
- Author:
Xiaoyan ZHU
;
Rongyao HOU
;
Hongwei XU
;
Yuchun WANG
;
Bo XIAO
;
Qidong YANG
;
Beisha TANG
- Publication Type:Journal Article
- Keywords:
Phosphatidylcholine-Sterol O-Acyltransferase;
Stroke;
Brain infarction;
Cerebral hemorrhage;
Atherosclerosis;
Polymorphism,genetic
- From:
International Journal of Cerebrovascular Diseases
2011;19(1):63-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between lecithin cholesterol acy ltransferase (LCAT) gene 608C/T and 511C/T polymorphisms and stroke in Chinese Han population in Hunan province. Methods One hundred fifty patients with cerebral infarction, 150patients with cerebral hemorrhage, and 122 age- and sex-matched healthy controls were selected.LCAT gene 608C/T and 511C/T polymorphisms were detected by using polyrnerase chain reaction, single strand conformation polymorphism, and restriction fragment length polymorphisms. Results The CT genotype frequency (14. 0% ) and T allele frequency (7. 0% )of the LCAT gene 608C/T in the cerebral infarction group were significantly higher than those in the control group (all P ＜0. 05), while there were no significant differences in the CT genotype frequency (7. 3% ) and T allele frequency (3.7%) between the cerebral hemorrhage group and the control group (P ＞ 0. 05). The CT genotype frequency (10. 0% ) and T allele frequency (5. 0% ) of the LCAT gene 511C/T in the cerebral infarction group were significantly higher than those in the control group (all P ＜0. 01), while there were no significant differences in the CT genotype frequency (3.3%) and T allele frequency (1.7%) between the cerebral hemorrhage group and the control group (P ＞0. 05). Conclusions The 608C/T and 511C/T polymorphisms may be associated with the occurrence of atherosclerotic cerebral infarction in Chinese Han population in Hunan province. They may be the predisposing factors for atherosclerotic cerebral infarction in this population; however, they are not associated with cerebral hemorrhage.
