Effects of Angong-niuhuang pill on expression of eNOSmRNA in spontaneously hypertensive rats after intracerebral hemorrhage
10.3760/cma.j.issn.1673-4246.2011.02.004
- VernacularTitle:安宫牛黄丸对自发性高血压大鼠脑出血后内皮型一氧化氮合酶信使核糖核酸表达的影响
- Author:
Yuanxin LIU
;
Ting LIU
;
Xiaoyan YANG
;
Hui LI
;
Yunqiao ZHANG
;
Huiwu LI
;
Jia LIU
;
Xinling MENG
;
Tao JIANG
;
Feng LIU
;
Xiaolu WANG
- Publication Type:Journal Article
- Keywords:
Angong-niuhuang Pills;
Intracerebral hemorrhage;
eNOSmRNA
- From:
International Journal of Traditional Chinese Medicine
2011;33(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Angong-niuhuang pill on expression of eNOSmRNA in spontaneously hypertensive rats after intracerebral hemorrhage and to explore it's protective mechanism.Methods 120 spontaneously hypertensive rats were randomly divided into four groups: model group, western medicine treated group. Angong-niuhuang pill treated group, combining traditional Chinese medicine western medicine group, expression of eNOSmRNA in rat brain tissue was detected by RT-PCR. Results Expression of BCL-2mRNA in combining traditional Chinese medicine western medicine group was significantly higer than other goups(P＜0.01), Compared with model group, the expression of BCL-2mRNA in western medicine treated group and Angong-niuhuang pill treated group was markedly increased (P＜0.01), the differences between Angong-niuhuang pill treated group and Western medicine treated group were not obvious (P＞0.05).Conclusion Protective effect of Angong-niuhuang pill on spontaneously hypertensive rats after intracerebral hemorrhage is related to the the inducement of eNOS expression.
