Effects of Gymnema Sylvestre on glucose-lipid metabolism and adipo-cytokines in Type 2 DM Rats
10.3760/cma.j.issn.1673-4246.2011.02.009
- VernacularTitle:匙羹藤对2型糖尿病大鼠胰岛素抵抗及脂肪细胞因子的影响
- Author:
Juane LI
;
Lei WANG
;
Lingling QIN
;
Tonghua LIU
- Publication Type:Journal Article
- Keywords:
Gymnema Sylvestre;
Diabetes mellitus;
Glucose-lipid metabolism;
Adipo-cytokines
- From:
International Journal of Traditional Chinese Medicine
2011;33(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Gymnema Sylvestre on glucose-lipid metabolism and adipo-cytokines in T2 DM Rats. Methods The T2 DM rats induced by high lipid diet and small dosage intraperitoneal injection of STZ, were randomly divided into model group (DM), high dose GS group (GSH),low dose GS group (GSL) and pioglitazone group (Pio, n= 8 in each). Each group has a DM inserted by gavage.Four weeks later, the levels of fasting blood glucose (FBG), serum insulin (INS), blood lipid (TG, CHOL, HDL and LDL), free fatty acdi (FFA), TNF-α, C-reactive protein (CRP)and adiponcetin(ADPN) were detected.Results Compare to model group, the levels of FBG, INS, Blood lipid, FFA, TNF-α and CRP were decreased in GSH and Pioglitazone groups, adiponcetin were increased in GSH and Pioglitazone groups, except in GSL group. Conclusion GS can improve the glucose-lipid metabolism disorder and insulin resistance in type 2diabetic mellitus rats. The mechanisms may be the amelioration of inflammatory response and adipocytokines,but still need further study to prove the conclusions.
