Effects of compound E-Jiao Slurry(CEJS)on the expression of VEGF in mice with lewis lung carcinoma

VernacularTitle:复方阿胶浆对移植性lewis肺癌组织血管内皮生长因子表达的影响
Author: Xumin SUN ; Xinyi CHEN
Publication Type:Journal Article
Keywords: Compound E-Jiao slurry; Lewis lung carcinoma xenografts; VEGF
From: International Journal of Traditional Chinese Medicine 2011;33(4):313-315
CountryChina
Language:Chinese
Abstract: Objective To observe the effects of CEJS combined with chemotherapy on the expression of VEGF in lewis lung carcinoma.Methods Tumor xenografts models were set up and randomly divided into five groups including control group,CTX CEJS,high-dose CEJS joint CTX(combination group 1),and middle-dose CEJS joint CTX(combination group 2).Paraffin imbedding and HE staining were performed,and the tissue Shape was observed by microscope after section.The expressions of VEGF in five groups were determined by immuno-histochemistry.Results The expression level of VEGF could be significantly down-regulated in CTX or combination group 1 and 2,compared with the control group(P＜0.05):CEJS group had no significant difference to the control group(P＞0.05);The average optical density in the combination group 1 and 2 showed no significantly difference to the CTX group(P＞0.05).Conclusion The inhibition of CEJS could not down regulate of the expression of VEGF,but CEJS could keep the affection of chemotherapy drugs on VEGF.