Research progress of acidic leucine-rich nuclear phosphoprotein 32E
10.3760/cma.j.issn.1673-422X.2011.04.002
- VernacularTitle:酸性核磷酸蛋白32E研究进展
- Author:
Hong YIN
;
Shui WANG
- Publication Type:Journal Article
- Keywords:
Genes,tumor suppressor;
Acidic leucine-rich nuclear phosphoprotein 32E
- From:
Journal of International Oncology
2011;38(4):246-247
- CountryChina
- Language:Chinese
-
Abstract:
Acidic leucine-rich nuclear phosphoprotein 32E (ANP32E) belongs to a family of acidic nuclear phosphoprotein 32, and participates in a broad range of biological processes. ANP32E is similar to ANP32A in structure. It has been suggested that the nueleo-cytoplasmic shuttling might be regulated by phosphorylation. ANP32E is able to inhibit the activity of PP2A. Recent findings indicate ANP32E acts as a tumor suppressing gene in mice fibrosarcoma, and is correlated with lung metastasis in the tumorigenesis of breast cancer. But the mechanism is not yet clear.
