Interleukin-27 signal pathways and tumor
10.3760/cma.j.issn.1673-422X.2011.04.004
- VernacularTitle:IL-27信号通路与肿瘤
- Author:
Cong ZHANG
;
Lihua LIU
;
Baoen SHAN
- Publication Type:Journal Article
- Keywords:
Interleukins;
Signal transduction;
Inflammation;
Neoplasms
- From:
Journal of International Oncology
2011;38(4):251-254
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin (IL)-27 is a new member of the IL-6/IL-12 family composed of p28 subunit and Epstein-Barr virus induced gene 3 (EBI3) subunit. Its receptor is composed of WSX-1 and gp130. It has dual properties including pro-inflammatory and anti-inflammatory function at different conditions. Studies have shown that IL-27 exerts its biological activities through stimulating JAK1/STAT1, JAK1/STAT3 signal pathways and regulating the production of Th1, Th17 as well as their related-cytokines. Furthermore, IL-27 can exert the role of anti-tumor activity by enhancing the effect of cytotoxic T cells and anti-angiogenesis.
