Antineoplastic properties of nitrogen-containing bisphosphoates
10.3760/cma.j.issn.1673-422X.2011.04.006
- VernacularTitle:含氮双磷酸盐的抗肿瘤作用
- Author:
Tingting HONG
;
Dong HUA
- Publication Type:Journal Article
- Keywords:
Bisphophonates;
Antineoplastic agents;
Angiogenesis inhibitors;
Immunomodulation
- From:
Journal of International Oncology
2011;38(4):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Nitrogen-containing bisphosphonates exert antitumor activity through induction of apoptosis or inhibition of proliferation, invasion and migration in tumor cells, inhibition of angiogenesis and promotion of immune surveillance. Animal models show that bisphosphonates delay visceral metastasis progression. Both ABCSG-12 and ZOFAST trial have demonstrated that Zoledronate reduced breast cancer recurrence risks. Bisphosphonates are synergistic with a variety of chemotherapeutics, and sequential dosing is more effective, which may be attributable to increased uptake of bisphosphonates by tumor cells after pretreatment with chemotherapeutics. Metronomic administration of bisphophonates after chemotherapy provides bisphosphonates the promising antineoplatic potential.
