Mechanisms of drug resistance for anti-VEGF therapy in tumor
10.3760/cma.j.issn.1673-422X.2011.04.007
- VernacularTitle:抗血管内皮生长因子药物治疗肿瘤的耐药机制
- Author:
Haitao CHEN
;
Quancai CAI
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Vascular endothelial growth factors;
Neovascularization,pathologic;
Drug resistance
- From:
Journal of International Oncology
2011;38(4):261-263
- CountryChina
- Language:Chinese
-
Abstract:
The resistance of anti-VEGF therapy which casually occurs during the course of tumor therapy by using anti-VEGF drugs may be associated with alternative angiogenesis signaling activation, bone marrowderived stem cells recruitment, pericyte coverage, perivascular invasion and so on. Thus, to investigate the mechanisms of drug resistance will guide us to understand deeply the relationship among normal tissues, tumors and drugs and to find out new therapeutic targets for anti-tumor therapy.
