Advances of RNAi in HPV16 E6/E7 of cervical cancer
10.3760/cma.j.issn.1673-422X.2011.04.018
- VernacularTitle:RNA干扰在宫颈癌HPV16E6/E7中的研究进展
- Author:
Chanjuan PENG
;
Feng YE
;
Xing XIE
- Publication Type:Journal Article
- Keywords:
RNA interference;
Uterine cervical neoplasms;
Human papillomavirus 16
- From:
Journal of International Oncology
2011;38(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
RNAi is a process of effective gene silencing. Human papillomaviruses 16 (HPV16), as the most prevalent genotype of cervical cancer, encodes the E6 and E7 oncogenes, which is pivotal for maintenance of malignant phenotypes. Recently, some significant advances have been obtained in RNA interfering effect on HPV16 E6/E7. In vitro, it has been developed more effective vector systems and screened for more specific targeted sequences. In vivo, the corresponding animal models have been established, which lay a good foundation for the clinical research.
