Changes of hypothalamus corticotropin releasing factor levels in children with acute brain injury
10.3760/cma.j.issn.1673-4912.2011.02.013
- VernacularTitle:急性脑损伤患儿下丘脑促肾上腺皮质激素释放因子水平的变化
- Author:
Jing DONG
;
Zhiyue XU
;
Jianshe CAO
;
Xiaoling YAO
;
Lihui ZHU
;
Yonghao GUI
;
Chao CHEN
;
Yimin ZHU
- Publication Type:Journal Article
- Keywords:
Brain injury;
Corticotrophin releasing factor;
Cytokine;
Glasgow coma scale score;
Children
- From:
Chinese Pediatric Emergency Medicine
2011;18(2):139-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of corticotropin releasing factor (CRF) levels secreted by hypothalamus neuron in children with acute brain injury. Methods Fifty-one intracranial-infection children with brain injury and 11 intracranial-noninfection children with brain injury were chosen from pediatric intensive care unit of our hospital. Severities of their brain damage were evaluated by Glasgow score,and CRF level in cerebrospinal fluid (CSF) and serum TNF-α and IL-6 levels were measured by radioimmunoassay. Results There was no significant difference of Glasgow scores between the intracranial infection group and intracranial-noninfection group ( P = 0. 302 6 ), CSF CRF level of intracranial infection group was significantly lower than that of intracranial-noninfection group ( P ＜ 0. 01 ), serum TNF-α and IL-6 levels of intracranial infection group were significantly higher than those of intracranial-noninfection group ( P ＜ 0. 01,P ＜0. 001 ). As comparing to the children with Glasgow score of 6 ～ 7, the levels of CSF CRF and serum TNF-α and IL-6 in children with Glasgow score of 4 ～ 5 were significantly increased ( P ＜ 0. 05, P ＜ 0. 001 ).Conclusion CSF CRF level of the children with acute brain injury is changing, which may be concerned with the secretion of hypothalamus CRF neuron stimulated by TNF-α, IL-6 and hypoxia stress in children with brain injury.
