The detection of Rotavirus and Norwalkvirus in stool and cerebrospinal fluid of children with infantile convulsions associated with mild gastroenteritis
10.3760/cma.j.issn.1673-4912.2011.01.014
- VernacularTitle:轻度胃肠炎伴婴幼儿惊厥患儿粪便及脑脊液轮状病毒及诺沃克病毒的检测及意义
- Author:
Xinguo LU
;
Jianxiang LIAO
;
Guifen ZHOU
;
Yan HU
;
Bing LI
;
Chunxi HAN
;
Tieshuan HUANG
- Publication Type:Journal Article
- Keywords:
Gastroenteritis;
Convulsions;
Rotavirus;
Norwalkvirus;
Infants
- From:
Chinese Pediatric Emergency Medicine
2011;18(1):39-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the common pathogen of infantile convulsions associated with mild gastroenteritis, and to study the differences between the seizures caused by the two kinds of virus.Methods RT-PCR was used to detect Rotavirus (RV) and Norwalkvirus (NoV) in stool and cerebrospinal fluid of 30 cases with infantile convulsions associated with mild gastroenteritis. The differences between the frequency of seizures caused by two kinds of virus were analyzed by statistical methods (two-sample t-test).Results 17/30 (56. 7%) were RV-positive in stool and 3/17 (17. 7%) in cerebrospinal fluid; 6/30 (25.0%) were NoV-positive in stool and 1/6 (16. 7%) in cerebrospinal fluid. The seizure frequency with NoV infection was (4. 33 ± 1.75) times, and RV infection patients was (2. 53 ± 1.12) times (P ＜ 0. 01).The seizure frequency of CSF virus-positive children was (4. 75 ± 1.71) times compared to (2. 63 ± 1.21)times in virus-negative children (P ＜ 0.01). Conclusion The common pathogens causing infantile convulsions associated with mild gastroenteritis were RV and NoV. The degree of NoV infection affecting the central nervous system may be greater than RV. The presence of the virus in cerebrospinal fluid may lead to higher incidence of seizures,but their exact roles related to the occurrence of seizures remain to be further studied.
