Expression of multidrug resistance protein in hepatocellular carcinoma and its clinical significance
10.3760/cma.j.issn.1673-4904.2011.11.006
- VernacularTitle:多药耐药蛋白在肝癌中的表达及临床意义
- Author:
Hongtao LIU
;
Zuguang WU
;
Xingxi LUO
;
Zhonghua CHU
;
Jianping LIU
;
Haigang LI
;
Tao CHEN
;
Haiyan ZHAO
;
Jie WANG
;
Qingjia OU
- Publication Type:Journal Article
- Keywords:
Immunohistochemistry;
Liver neoplasms;
Drug therapy;
Multidrug resistanceassociated proteins
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(11):14-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of multidrug resistance protein such as multidrug resistance-associated protein 1 (MRP1),lung-resistance related protein (LRP), P-glycoprotein (Pgp),glutathione s-transferase (GST-π) and topoismerase Ⅱ (TOPO Ⅱ ) in hepatocellular carcinoma (HCC), which would be supplied for the clinical chemotherapy of HCC. Methods Twenty-six cases of HCC who underwent hepatectomy were enrolled and immunohistochemical (IHC) staining was carried out on all specimens for the detection of expression of MRP1,LRP,Pgp,GST-πand TOPO Ⅱ and the data was analyzed by image analysis system. Results The expression of five multidrug resistance protein in HCC tissue were significantly higher than those in adjacent tissue beyond cancer (P ＜0.05). The significant differences were found in the expression of Pgp,TOPO Ⅱ and GST-π between HCC tissue and distant metastasis (P ＜ 0.05 ). The expression of the five multidrug resistance protein in poorly differentiated HCC tissue was higher than that in well-differentiated tissue,while the significant difference was only found in the expression of TOPO Ⅱ (P ＜ 0.05 ). The significant association was not found between the expressions of five multidrug resistance protein in HCC tissue and the size of tumor,AFP, the portal vein tumor thrombus,hepatic cirrhosis and liver function. Conclusions Five multidrug resistance protein overexpression in various degrees in HCC tissue, which relates to some biological behavior of the cancer. Combined detection is of much benefit to the choice of the drug of chemotherapy and to the prediction of prognosis.
